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Exciting News from the Linda Crnic Institute:
Nationally renowned pediatrician and geneticist, Edward R.B. McCabe, MD, PhD, has been tapped to become the first Executive Director of the Linda Crnic Institute for Down Syndrome at the University of Colorado School of Medicine. McCabe brings unparalleled experience and a lifelong commitment to pediatric genetic disorders to his new position headquartered on the Anschutz Medical Campus. McCabe is leaving a distinguished position as Physician-in-Chief and Executive Endowed Chair in Pediatrics at the Mattel Children’s Hospital at UCLA.
Read the full press release here!

Edward R.B. McCabe, MD, PhD
The Linda Crnic Institute for Down Syndrome aims to eradicate the ill effects associated with Down syndrome and significantly improve the lives of people with Down syndrome throughout the world.
With the Anna and John J. Sie Foundation commitment of $34 million, the Institute will be a global beacon for research and care. it will be the first national organization to comprehensively engage in basic research, clinical research and clinical care. It will integrate the highest quality basic, translational and clinical research, clinical trials, therapeutic development, medical care, education and advocacy.
The inspiration for the establishment of the Linda Crnic Institute is Sophia Kay Whitten, the granddaughter of Anna and John J. Sie who happens to have Down syndrome.
Named in memory of Dr. Linda Crnic
- Professor of Pediatrics and Psychiatry and Director of the Colorado Mental Retardation and Developmental Disabilities Center, who died in a bicycle accident in 2004
- In honor of her unwavering dedication to people with Down syndrome through translational research
Institute Umbrella Partners
- University of Colorado Denver School of Medicine
- University of Colorado at Boulder
- The Children's Hospital in Aurora, Colo.
- Anna and John J. Sie Foundation
Location
- Headquartered at the University of Colorado Denver's Anschutz Medical Campus, including 10,000 square feet of research space
- Basic research laboratories at the University of Colorado at Boulder
- Clinical care facilities for the Anna and John J. Sie Center for Down Syndrome at The Children's Hospital representing several thousand square feet when at full capacity
Mission
- Significantly improve the lives of all people with Down syndrome
- Eradicate the ill effects associated with Down syndrome (having an extra chromosome 21)
Vision
- Provide the world's first "cradle-to-cradle," fully integrated institute for Down syndrome with the highest quality basic, translational and clinical research, clinical trials, therapeutic development, medical care, education and advocacy in the pursuit of the mission
- Change the paradigm of how people with Down syndrome are perceived by society
- Serve as the Anschutz Medical Campus gold standard for translational research for Colorado and the gold standard worldwide
Values
- Excellence: Hire and inspire the best management team, scientists and medical talent that dedicate their lives to making a difference.
- Leadership: Lead with clarity of vision and implementation. Have courage to embark down new paths, have new ideas and to measure outcomes. Inspire others to join us.
- Respect and Trust: Hold the highest regard for children and adults with Down syndrome and their families. Earn and maintain the trust of our patients, families, scientific communities and our partners.
- Hope: Inspire hope in people with Down syndrome, their families, caregivers and all who touch their lives.
- Accountability: Hold the highest standard of accountability for our scientific outcomes, to our donors and investors, and above all, to people with Down syndrome, and all who touch their lives.
Uniqueness of LCI
- No research institute has declared the full solution of the DS genetic disorder as it's goal
- No medical institute encompasses basic scientific research, clinical trials and medical health care under one roof
Why LCI will Succeed
- Unique vision and right timing
- Committed partners
- Compelling incentive for faculty
- Ability and desire to make a difference for people with Down syndrome
- Strong community support
- Extraordinary and enlightened public/private enterprise
Please visit the Linda Crnic Institute's website for more information.
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